Bayesian Optimization (BO) has been widely used to efficiently optimize expensive black-box functions with limited evaluations. In this paper, we investigate the use of BO for prompt engineering to enhance text classification with Large Language Models (LLMs). We employ an LLM-powered Gaussian Process (GP) as the surrogate model to estimate the performance of different prompt candidates. These candidates are generated by an LLM through the expansion of a set of seed prompts and are subsequently evaluated using an Upper Confidence Bound (UCB) acquisition function in conjunction with the GP posterior. The optimization process iteratively refines the prompts based on a subset of the data, aiming to improve classification accuracy while reducing the number of API calls by leveraging the prediction uncertainty of the LLM-based GP. The proposed BO-LLM algorithm is evaluated on two datasets, and its advantages are discussed in detail in this paper.

Although recent advances in quantum machine learning (QML) offer significant potential for enhancing generative models, particularly in molecular design, a large array of classical approaches still face challenges in achieving high fidelity and validity. In particular, the integration of QML with sequence-based tasks, such as Simplified Molecular Input Line Entry System (SMILES) string reconstruction, remains underexplored and usually suffers from fidelity degradation. In this work, we propose a hybrid quantum-classical architecture for SMILES reconstruction that integrates quantum encoding with classical sequence modeling to improve quantum fidelity and classical similarity. Our approach achieves a quantum fidelity of approximately 84% and a classical reconstruction similarity of 60%, surpassing existing quantum baselines. Our work lays a promising foundation for future QML applications, striking a balance between expressive quantum representations and classical sequence models and catalyzing broader research on quantum-aware sequence models for molecular and drug discovery.

Non-emergency municipal services such as city 311 systems have been widely implemented across cities in Canada and the United States to enhance residents' quality of life. These systems enable residents to report issues, e.g., noise complaints, missed garbage collection, and potholes, via phone calls, mobile applications, or webpages. However, residents are often given limited information about when their service requests will be addressed, which can reduce transparency, lower resident satisfaction, and increase the number of follow-up inquiries. Predicting the service time for municipal service requests is challenging due to several complex factors: dynamic spatial-temporal correlations, underlying interactions among heterogeneous service request types, and high variation in service duration even within the same request category. In this work, we propose MuST2-Learn: a Multi-view Spatial-Temporal-Type Learning framework designed to address the aforementioned challenges by jointly modeling spatial, temporal, and service type dimensions. In detail, it incorporates an inter-type encoder to capture relationships among heterogeneous service request types and an intra-type variation encoder to model service time variation within homogeneous types. In addition, a spatiotemporal encoder is integrated to capture spatial and temporal correlations in each request type. The proposed framework is evaluated with extensive experiments using two real-world datasets. The results show that MuST2-Learn reduces mean absolute error by at least 32.5%, which outperforms state-of-the-art methods.

Clinical summarization is crucial in healthcare as it distills complex medical data into digestible information, enhancing patient understanding and care management. Large language models (LLMs) have shown significant potential in automating and improving the accuracy of such summarizations due to their advanced natural language understanding capabilities. These models are particularly applicable in the context of summarizing medical/clinical texts, where precise and concise information transfer is essential. In this paper, we investigate the effectiveness of open-source LLMs in extracting key events from discharge reports, including admission reasons, major in-hospital events, and critical follow-up actions. In addition, we also assess the prevalence of various types of hallucinations in the summaries produced by these models. Detecting hallucinations is vital as it directly influences the reliability of the information, potentially affecting patient care and treatment outcomes. We conduct comprehensive simulations to rigorously evaluate the performance of these models, further probing the accuracy and fidelity of the extracted content in clinical summarization. Our results reveal that while the LLMs (e.g., Qwen2.5 and DeepSeek-v2) perform quite well in capturing admission reasons and hospitalization events, they are generally less consistent when it comes to identifying follow-up recommendations, highlighting broader challenges in leveraging LLMs for comprehensive summarization.

Shared micromobility (e.g., shared bikes and electric scooters), as a kind of emerging urban transportation, has become more and more popular in the world. However, the blooming of shared micromobility vehicles brings some social problems to the city (e.g., overloaded vehicles on roads, and the inequity of vehicle deployment), which deviate from the city regulator's expectation of the service of the shared micromobility system. In addition, the multi-operator shared micromobility system in a city complicates the problem because of their non-cooperative self-interested pursuits. Existing regulatory frameworks of multi-operator vehicle rebalancing generally assume the intrusive control of vehicle rebalancing of all the operators, which is not practical in the real world. To address this limitation, we design REALISM, a regulatory framework for coordinated scheduling in multi-operator shared micromobility services that incorporates the city regulator's regulations in the form of assigning a score to each operator according to the city goal achievements and operators' individual contributions to achieving the city goal, measured by Shapley value. To realize the fairness-aware score assignment, we measure the fairness of assigned scores and use them as one of the components to optimize the score assignment model. To optimize the whole framework, we develop an alternating procedure to make operators and the city regulator interact with each other until convergence. We evaluate our framework based on real-world e-scooter usage data in Chicago. Our experiment results show that our method achieves a performance gain of at least 39.93% in the equity of vehicle usage and 1.82% in the average demand satisfaction of the whole city.

Land cover, both present and future, has a significant effect on several important Earth system processes. For example, impervious surfaces heat up and speed up surface water runoff and reduce groundwater infiltration, with concomitant effects on regional hydrology and flood risk. While regional Earth System models have increasing skill at forecasting hydrologic and atmospheric processes at high resolution in future climate scenarios, our ability to forecast land-use and land-cover change (LULC), a critical input to risk and consequences assessment for these scenarios, has lagged behind. In this paper, we propose a new paradigm exploiting Generative AI (GenAI) for land cover change forecasting by framing LULC forecasting as a data synthesis problem conditioned on historical and auxiliary data-sources. We discuss desirable properties of generative models that fundament our research premise, and demonstrate the feasibility of our methodology through experiments on imperviousness forecasting using historical data covering the entire conterminous United States. Specifically, we train a diffusion model for decadal forecasting of imperviousness and compare its performance to a baseline that assumes no change at all. Evaluation across 12 metropolitan areas for a year held-out during training indicate that for average resolutions $\geq 0.7\times0.7km^2$ our model yields MAE lower than such a baseline. This finding corroborates that such a generative model can capture spatiotemporal patterns from historical data that are significant for projecting future change. Finally, we discuss future research to incorporate auxiliary information on physical properties about the Earth, as well as supporting simulation of different scenarios by means of driver variables.

Large Language Models (LLMs) are increasingly applied to medical imaging tasks, including image interpretation and synthetic image generation. However, these models often produce hallucinations, which are confident but incorrect outputs that can mislead clinical decisions. This study examines hallucinations in two directions: image to text, where LLMs generate reports from X-ray, CT, or MRI scans, and text to image, where models create medical images from clinical prompts. We analyze errors such as factual inconsistencies and anatomical inaccuracies, evaluating outputs using expert informed criteria across imaging modalities. Our findings reveal common patterns of hallucination in both interpretive and generative tasks, with implications for clinical reliability. We also discuss factors contributing to these failures, including model architecture and training data. By systematically studying both image understanding and generation, this work provides insights into improving the safety and trustworthiness of LLM driven medical imaging systems.

This study presents a multimodal AI framework designed for precisely classifying medical diagnostic images. Utilizing publicly available datasets, the proposed system compares the strengths of convolutional neural networks (CNNs) and different large language models (LLMs). This in-depth comparative analysis highlights key differences in diagnostic performance, execution efficiency, and environmental impacts. Model evaluation was based on accuracy, F1-score, average execution time, average energy consumption, and estimated $CO_2$ emission. The findings indicate that although CNN-based models can outperform various multimodal techniques that incorporate both images and contextual information, applying additional filtering on top of LLMs can lead to substantial performance gains. These findings highlight the transformative potential of multimodal AI systems to enhance the reliability, efficiency, and scalability of medical diagnostics in clinical settings.

With the rapid advancements in large language model (LLM) technology and the emergence of bioinformatics-specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational characteristics, and diverse applications. This survey aims to address this need by providing a thorough review of BioLMs, focusing on their evolution, classification, and distinguishing features, alongside a detailed examination of training methodologies, datasets, and evaluation frameworks. We explore the wide-ranging applications of BioLMs in critical areas such as disease diagnosis, drug discovery, and vaccine development, highlighting their impact and transformative potential in bioinformatics. We identify key challenges and limitations inherent in BioLMs, including data privacy and security concerns, interpretability issues, biases in training data and model outputs, and domain adaptation complexities. Finally, we highlight emerging trends and future directions, offering valuable insights to guide researchers and clinicians toward advancing BioLMs for increasingly sophisticated biological and clinical applications.

Identifying mutations of SARS-CoV-2 strains associated with their phenotypic changes is critical for pandemic prediction and prevention. We compared an explainable convolutional neural network (CNN) approach and the traditional genome-wide association study (GWAS) on the mutations associated with WHO labels of SARS-CoV-2, a proxy for virulence phenotypes. We trained a CNN classification model that can predict genomic sequences into Variants of Concern (VOCs) and then applied Shapley Additive explanations (SHAP) model to identify mutations that are important for the correct predictions. For comparison, we performed traditional GWAS to identify mutations associated with VOCs. Comparison of the two approaches shows that the explainable neural network approach can more effectively reveal known nucleotide substitutions associated with VOCs, such as those in the spike gene regions. Our results suggest that explainable neural networks for genomic sequences offer a promising alternative to the traditional genome wide analysis approaches.